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Synthesis of 6-[18F]fluorodopamine, 6-[18F]fluoro-m-tyramine and 4-[18F]fluoro-m-tyramine+

✍ Scribed by Mohammad Namavari; N. Satyamurthy; Jorge R. Barrio

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
376 KB
Volume
36
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A new method for the preparation of 6‐[^18^F]fluorodopamine (3) and [^18^F]fluorinated analogs of m‐tyramine based on a regioselective radiofluorodestannylation reaction has been developed. The radiofluorodestannylation of 6‐trimethylstannyldopamine derivative 1 was carried out with [^18^F]F~2~ to give the corresponding [^18^F]fluoro intermediate 2. Acid deprotection of 2 with 48% HBr followed by HPLC purification afforded 6‐[^18^F]fluorodopamine (3) in 18% radiochemical yield. Similarly, 6‐ and 4‐[^18^F]fluoro‐m‐tyramines (6a and 6b) were prepared from their corresponding trimethylstannyl‐m‐tyramine derivatives in 25 and 8% radiochemical yields, respectively. In all cases, after HPLC purification of the final products, tin concentrations were found to be <15 ppb.

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