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Alternative solvents for electrophilic synthesis of 6-[18F]fluoro-L-DOPA

✍ Scribed by Sarita Forsback; Olli Eskola; Jörgen Bergman; Merja Haaparanta; Olof Solin

Publisher
John Wiley and Sons
Year
2009
Tongue
French
Weight
95 KB
Volume
52
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Owing to the ozone layer‐depleting properties of chlorofluorocarbon compounds, alternative solvents for electrophilic fluorination reactions are desirable. Chloroform, dichloromethane, acetone or their deuterated analogues were examined as substitutes for Freon‐11 in the electrophilic synthesis of 6‐[^18^F]fluoro‐L‐DOPA ([^18^F]FDOPA). CDCl~3~, CD~2~Cl~2~ and C~3~D~6~O were found to be suitable solvents in this reaction, with the deuterated solvents providing significantly higher yields than Freon‐11. There were no differences among the solvents in the specific radioactivity, the radiochemical purity, the chemical purity or the microbiological quality of the final product. However, the radiochemical yield of [^18^F]FDOPA was increased when acetic acid was added to the precursor solution prior to the fluorination reaction. Copyright © 2009 John Wiley & Sons, Ltd.

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