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Synthesis and enzymatic decarboxylation of 6-bromo-L-dopa, a potential brain tracer for L-dopa

✍ Scribed by Michael Wong; Onofre T. de Jesus

Publisher: John Wiley and Sons
Year: 1987
Tongue: French
Weight: 288 KB
Volume: 24
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580241114

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✦ Synopsis

Direct brominatbn of L-dopa with stoichbmetric amounts of molecular bromine was found to yield 6-bromo-L-dopa as the sole product. This determination was made using liquid chromatography with electrochemical detector, mass spectroscopy, and proton NMR. 6-Bromo-L-dopa was found to be a substrate of an isolated decarboxylase enzyme although the rate of decarboxylation was much slower than that for L-dopa. These results suggest that a radiobrominated L-dopa a n a h may be a suitable PET or SPECT tracer for L-dopa in the brain.

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