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Synthesis and preliminary evaluation of L-6-[123I]Iododopa as a potential spect brain imaging agent

โœ Scribed by Michael J. Adam; Yolanda Zea Ponce; Joffre M. Berry; Kevin Hoy

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
483 KB
Volume
28
Category
Article
ISSN
0022-2135

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โœฆ Synopsis

A bst rnct in buffer(pH 4) for 35 minutes at 97ยฐC. The synthesis was complete in approximately 1 hour with a radiochemical yield of 50% , a specific activity of 65 Ci/mmol and a radiochemical purity of >95%. A non radioactive standard of L-6-iododopa was synthesized by the iododemercuration of a mercury-dopa derivative using 12 in chloroform. It was shown that L-6-['231]iododopa accumulated in the rat striatum with striatum:whole brain ratio of 1.36 a t 1 hour and 1.11 at 2 hours.

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