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Synthesis of 4-dihydroxyboryl-2-[18F]fluorophenylalanine with relatively high-specific activity

✍ Scribed by Jyrki K. Vähätalo; Olli Eskola; Jörgen Bergman; Sarita Forsback; Pertti Lehikoinen; Juha Jääskeläinen; Olof Solin

Publisher
John Wiley and Sons
Year
2002
Tongue
French
Weight
130 KB
Volume
45
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

An alternative procedure to produce 4‐dihydroxyboryl‐2‐[^18^F]fluorophenylalanine ([^18^F]FBPA) for positron emission tomography studies in boron neutron capture therapy is described. Relatively high‐specific activity electrophilic radiofluorine is produced using a post‐target conversion of [^18^F]F^–^ to [^18^F]F~2~. Liquid chromatography with mass spectrometric detection is used to estimate the specific radioactivity of [^18^F]FBPA and to verify the quality control for chemical identity of the target compound. [^18^F]FBPA produced according to this method fulfilled the pharmaceutical quality requirements for an injection in patients. Copyright © 2002 John Wiley & Sons, Ltd.

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