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Microwave-assisted cyclocondensation of 1,2-diaminobenzene with [4-18F]fluorobenzoic acid: microwave synthesis of 2-([4-18F]fluorophenyl) benzimidazole

✍ Scribed by Gareth Getvoldsen; Anna Fredriksson; Nils Elander; Sharon Stone-Elander

Publisher
John Wiley and Sons
Year
2004
Tongue
French
Weight
99 KB
Volume
47
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis of 2‐([4‐^18^F]fluorophenyl)benzimidazole, which has potential to be used as a building block for many endogenous and pharmaceutical compounds, is reported. A range of solvents and catalysts as well as conventional and microwave heating have been investigated to optimise the reaction conditions. The cyclocondensation of 1,2‐diaminobenzene with radiolabelled [4‐^18^F]fluorobenzoic acid in neat methanesulphonic and polyphosphoric acids under microwave heating led rapidly to the cyclised phenylbenzimidazole. Copyright © 2004 John Wiley & Sons, Ltd.

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