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The comparative synthesis of 18F-fluorophenylalanines by electrophilic substitution with 18F-F2 and 18F-AcOF

✍ Scribed by M. Murakami; K. Takahashi; Y. Kondo; S. Mizusawa; H. Nakamichi; H. Sasaki; E. Hagami; H. Iida; I. Kanno; S. Miura; K. Uemura

Publisher
John Wiley and Sons
Year
1988
Tongue
French
Weight
181 KB
Volume
25
Category
Article
ISSN
0022-2135

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✦ Synopsis

Fluorination with 18F-F2 and 18F-AcOF were compared for the synthesis of 18F-fluorophenylalanines. L-phenylalanine in CF,COOH trapped 18F-AcOF more effectively than 18F-F2. The main product was ortho-18F-fluorophenylalanine when 18F-AcOF was used as a reagent. Lower radiochemical yield of 18F-fluorophenylalanines and si nificant formation of by-product were observed in the case o f feF-F,.

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