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Rapid Synthesis of 3-[18F]Fluoro-l-(2′-Nitro-1′-Imidazolyl)-2-Propanol ([18F]Fluoromisonidazole)

✍ Scribed by Abdallah Cherif; David J. Yang; Wayne Tansey; E. Edmund Kim; Sidney Wallace

Book ID
110379792
Publisher
Springer US
Year
1994
Tongue
English
Weight
641 KB
Volume
11
Category
Article
ISSN
0724-8741

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✍ Chi-Ching Yang; Irving H. Goldberg 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 French ⚖ 499 KB

A short, efficient synthesis for 1-(2-[180 2 ] -n i t r o -1 -i m i d a z o l y l ) -3methoxy-2-propanol ( [ I 8 0 2] -misonidazole) from 2-aminoimidazole is described. The required 180-labeled sodium nitrite (82.6 atom %) was conveiently synthesized by the treatment of sodium nitrite with DOWEX SOW