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Enantiospecific synthesis of 2-[18F]fluoro-l-phenylalanine and 2-[18F]fluoro-l-tyrosine by isotopic exchange

✍ Scribed by Castillo Meleán, Johnny ;Ermert, Johannes ;Coenen, Heinz H.

Book ID
120060121
Publisher
Royal Society of Chemistry
Year
2011
Tongue
English
Weight
179 KB
Volume
9
Category
Article
ISSN
1477-0520

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Synthesis of 6-[18F] and 4-[18F]fluoro-l-m-tyrosines via regioselective radiofluorodestannylation
✍ Mohammad Namavari; N. Satyamurthy; Michael E. Phelps; Jorge R. Barrio 📂 Article 📅 1993 🏛 Elsevier Science 🌐 English ⚖ 960 KB

The regioselective radiofluorodestannylation of 6-trimethylstannyl-L-m-tyrosine derivative 6 with [18F]F2 and [18F]acetyl hypofluorite afforded, after acid hydrolysis, 6-[18F]fluoro-L-m-tyrosine (8a) in radiochemical yields of 23 and 17%, respectively. Similarly, 4-[18F]fluoro-L-m-tyrosine (13a) was