## Abstract Owing to the ozone layerβdepleting properties of chlorofluorocarbon compounds, alternative solvents for electrophilic fluorination reactions are desirable. Chloroform, dichloromethane, acetone or their deuterated analogues were examined as substitutes for Freonβ11 in the electrophilic s
Co production of 2,6-[18F] difluoroDOPA during electrophilic synthesis of 6-[18F]fluoro-l-DOPA
β Scribed by Kentaro Hatano; Kiichi Ishiwata; Touru Yanagisawa
- Book ID
- 117688133
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 280 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0969-8051
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π SIMILAR VOLUMES
Previous work from this laboratory has shown that the direct fluorination of 3, 4-dihydroxy-phenyl-lalanine (l-DOPA) in anhydrous HF (aHF) or BF 3 /HF with F 2 is an efficient method for the synthesis of 6-fluoro-l-DOPA. Since then, 18 F-labeled 6-fluoro-l-DOPA ([ 18 F]6-fluoro-l-DOPA) has been used
A protected 6-trimethylstannyl dopa derivative 6 has been synthesized for the first time as a precursor for the preparation of 6-[18F]fluoro-L-dopa. The tin derivative 6 readily reacted with electrophilic radiofluorinating agents such as [18F]F2 and [18F]AcOF. The [18F]fluoro intermediate 7 was easi