## Abstract Progression of Parkinson's disease symptoms is imperfectly correlated with positron emission tomography biomarkers for dopamine biosynthetic pathways. The radiopharmaceutical 6โ[^18^F]fluoroโmโtyrosine is not a substrate for catecholโ__O__โmethyltransferase and therefore has a more favo
Evaluation of Dopaminergic Presynaptic Integrity: 6-[18F]Fluoro-L-Dopa Versus 6-[18F]Fluoro-L-m-Tyrosine
โ Scribed by Doudet, D. J.; Chan, G. L.-Y.; Jivan, S.; DeJesus, O. T.; McGeer, E. G.; English, C.; Ruth, T. J.; Holden, J. E.
- Book ID
- 110078968
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 546 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0271-678X
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The regioselective radiofluorodestannylation of 6-trimethylstannyl-L-m-tyrosine derivative 6 with [18F]F2 and [18F]acetyl hypofluorite afforded, after acid hydrolysis, 6-[18F]fluoro-L-m-tyrosine (8a) in radiochemical yields of 23 and 17%, respectively. Similarly, 4-[18F]fluoro-L-m-tyrosine (13a) was