𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of [3H]win 35,065-2; A new radioligand for cocaine receptors

✍ Scribed by T. M. Naseree; P. Abraham; J. A. Kepler; F. I. Carroll; A. H. Lewin; M. J. Kuhar

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
226 KB
Volume
28
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Treatment of methyl (‐)‐3β‐phenylnortropane‐2β‐carboxylate with [^3^H]CH~3~I afforded [^3^H]WIN 35,065‐2 with specific activity of 25 Ci/mmol, a new ligand for the cocaine recognition site.

📜 SIMILAR VOLUMES

Synthesis of [3H]fenobam, a radioligand
Synthesis of [3H]fenobam, a radioligand for the mGlu5 receptor
✍ Thomas Hartung; Jens-Uwe Peters; Jürgen Wichmann; Christian Hubschwerlen; Georg 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 102 KB

## Abstract Fenobam is a clinically efficacious anxiolytic that acts as metabotropic glutamate receptor 5 (mGlu5) antagonist by binding to an allosteric site. Other mGlu5 receptor antagonists such as MPEP and MTEP bind to the same allosteric site and are efficacious in preclinical models of anxiety

[3H]imidacloprid: Synthesis of a candida
[3H]imidacloprid: Synthesis of a candidate radioligand for the nicotinic acetylcholine receptor
✍ Bachir Latli; John E. Casida 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 French ⚖ 192 KB

## Abstract Imidacloprid is an exceptionally potent insecticide known from physiological studies to act at the nicotinic acetylcholine receptor. To prepare [^3^H]imidacloprid as a candidate radioligand, 6‐chloronicotinoyl chloride was reduced with NaB^2^H~4~ (in model studies) or NaB^3^H~4~ in abso

Synthesis of [3H]CP-93,129: A selective
Synthesis of [3H]CP-93,129: A selective radioligand for the 5-HT1B receptor
✍ John E Macor; Kevin Ryan; Phillip M. Chalabi; James C. Windels; Robert W. Roth 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 French ⚖ 413 KB

## Abstract The synthesis of [^3^H]‐CP‐93,129, a potent radioligand for the serotonin 5‐HT~1B~ receptor, is described. 5‐Butoxypyrrolo[3,2‐b]pyridine (2) is converted in 3 steps to 5‐butoxy‐1‐phenylsulfonyl‐2‐tritiopyrrolo[3,2‐b]pyridine (3c) via lithiation of C2, iodination of that anion, and trit