Synthesis of [18F]-1-(3-Fluoropropyl)-4-
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T. Lee Collier; Joanne C. O'Brien; Rikki N. Waterhouse
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Article
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1996
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John Wiley and Sons
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French
⚖ 467 KB
~F]-1-(3-Fluoropropyl)-4-(4-cyanophenoxymethyl)piperidine has been prepared as a potential sigma-I receptor ligand for PET. The unlabeled ligand was found to be selective in vitro for the sigma-I receptor [Ki(crl) = 4.3 nM] when tested in a variety of neuroreceptor binding assays. Furthermore, the l