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Synthesis of [3H]CP-93,129: A selective radioligand for the 5-HT1B receptor

✍ Scribed by John E Macor; Kevin Ryan; Phillip M. Chalabi; James C. Windels; Robert W. Roth

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
413 KB
Volume
28
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis of [^3^H]‐CP‐93,129, a potent radioligand for the serotonin 5‐HT~1B~ receptor, is described. 5‐Butoxypyrrolo[3,2‐b]pyridine (2) is converted in 3 steps to 5‐butoxy‐1‐phenylsulfonyl‐2‐tritiopyrrolo[3,2‐b]pyridine (3c) via lithiation of C2, iodination of that anion, and tritium reduction. (3c) is converted to the title compound in two more steps analogous to methodology used in the synthesis of CP‐93,129, a potent and selective 5‐HT~1B~ agonist.

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