Synthesis of 2-[18F]fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine, a highly potent radioligand for in vivo imaging central nicotinic acetylcholine receptors
✍ Scribed by Frédéric Dolle; Héric Valette; Michel Bottlaender; Françoise Hinnen; Françoise Vaufrey; Ilonka Guenther; Christian Crouzel
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- French
- Weight
- 633 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0022-2135
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## Abstract 6‐Chloro‐3‐((2‐(__S__)‐azetidinyl)methoxy)‐5‐((__E__)‐2‐(2‐[^18^F]fluoropyridin‐4‐yl)vinyl)pyridine ([^18^F]NIDA 52289), a very high affinity radioligand for studying nicotinic acetylcholine receptors (nAChRs) by positron‐emission tomography, was synthesized through Kryptofix 222 assist
## Abstract 6‐Chloro‐3‐((2‐(__S__)‐azetidinyl)methoxy)‐5‐(2‐[^18^F]fluoropyridin‐4‐yl)pyridine ([^18^F]NIDA 522131), a potential radioligand for studying extrathalamic nicotinic acetylcholine receptors by positron‐emission tomography, was synthesized via no‐carrier‐added nucleophilic [^18^F]fluorin