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Synthesis of [3H]-labelled glucobrassicin, a potential radiotracer for metabolic studies of indole glucosinolates

✍ Scribed by S. Chevolleau; B. Joseph; P. Rollin; J. Tulliez

Publisher
John Wiley and Sons
Year
1993
Tongue
French
Weight
401 KB
Volume
33
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Glucobrassicin, an indole glucosinolate widespread in cruciferous plants, appears to be involved in anticarcinogenic activity via its breakdown products. In order to study the “in vivo” metabolism of glucobrassicin, we have synthesized the 5‐[^3^H]‐indol‐3‐ylmethyl glucosinolate (^3^H‐labelled glucobrassicin) starting from artificial peracetylated 5‐bromoindol‐3‐ylmethyl glucosinolate. The labelled compounds were characterized by radio‐HPLC and FAB mass spectrometry.

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