Synthesis Of N,N-dimethyl-[β-(3,4-diacetoxy-6-123I-iodophenyl)]-ethylamine (IDDE): A potential radiotracer for the study of the dopaminergic system

✍ Scribed by Michael J. Adam; Yolanda Zea Ponce; Joffre M. Berry; Jianming Lu

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: French
• Weight: 415 KB
• Volume: 31
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580310103

✦ Synopsis

Abstract

N.N‐Dimethyl‐[β‐(3,4‐Diacetoxy‐6‐^123^I‐Iodophenyl)]ethylamine (IDDE) was synthesized by the iododemercuration reaction with [^123^I]‐NaI and Chloramine‐T. The iodinated compound was deprotected with BBr~3~, acetylated and purified by HPLC to give the final product in 43% radiochemical yield. The radiochemical purity was >97%.