✦ LIBER ✦

Synthesis of H-3 labeled 5-fluoro-3-[3-[4-(5-methoxy-4-pyrimidinyl)-1-piperazinyl]propyl]-1H-indole, a serotonergic agent with potential antidepressant activity

✍ Scribed by Douglas D. Dischino; Keith D. Combrink; Lidia Doweykos; Hiromi Morimoto; Bradley C. Pearce; Philip G. Williams; Joseph P. Yevich

Publisher: John Wiley and Sons
Year: 1995
Tongue: French
Weight: 235 KB
Volume: 36
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580360810

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The title compound was prepared by the LiAlT~4~ reduction of 5‐fluoro‐3‐[3‐[4‐(5‐methoxy‐4‐pyrimidinyl)‐1‐piperazinyl]‐3‐oxopropyl]‐1H‐indole. The radiochemical purity of the product was 98.9% and the specific activity was calculated as 53.0 Ci/mmol from HPLC analyses and 55.6 Ci/mmol from ^3^H NMR measurements.

📜 SIMILAR VOLUMES

ChemInform Abstract: Process Development

ChemInform Abstract: Process Development of 5-Fluoro-3-(3-(4-(5-methoxy-4-pyrimidinyl)-1- piperazinyl)propyl)-1H-indole Dihydrochloride.

✍ N. G. ANDERSON; J. A. GROSSO; ET AL. ET AL. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 26 KB 👁 1 views

Synthesis of 5-fluoro-3-[3-[4-(2-[14C]-5

Synthesis of 5-fluoro-3-[3-[4-(2-[14C]-5-methoxy-4-pyrimidinyl)-1piperazinyljpropypiperazinyl]propyl]-1H-indole dihydrochloride

✍ Ute J. Haynes; J. E. Swigor 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 209 KB

## Abstract The synthesis of 5‐Fluoro‐3‐[3‐[4‐(2‐[^14^C]‐5‐methoxy‐4‐pyrimi‐dinyl)‐1‐piperazinyl]propyl]‐1H‐indole dihydrochloride (5) was achieved by coupling [^14^C] formamidine acetate (1) and dimethylmethoxymalonate in methanol containing sodium methoxide at 60°C to provide 2‐[^14^C] 4,6‐dihydr

ChemInform Abstract: 3,4-Dihydro-2(1H)-q

ChemInform Abstract: 3,4-Dihydro-2(1H)-quinolinone as a Novel Antidepressant Drug: Synthesis and Pharmacology of 1-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl] -3,4-dihydro-5-methoxy-2(1H)-quinolinone and Its Derivatives.

✍ Yasuo Oshiro; Yoji Sakurai; Seiji Sato; Nobuyuki Kurahashi; Tatsuyoshi Tanaka; T 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 35 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Regioselective Synthesis of 3-Aryl-5-(1H

Regioselective Synthesis of 3-Aryl-5-(1H-indole-3-carbonyl)-4-hydroxyfuroic Acids as Potential Insulin Receptor Activators.

✍ Shan-Yen Chou; Shieh-Shung Tom Chen; Ching-Hui Chen; Lien-Shange Chang 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 56 KB

ChemInform Abstract: Synthesis of Indolo

ChemInform Abstract: Synthesis of Indolo[2′,3′:5,6][1,2,4]triazino[4,3-a][1,8]naphthyridines and 3′-(3-Phenyl-1,8-naphthyridin-2-ylamino)spiro [3H-indole-3,2′-thiazolidine]-2,4′(1H)-diones as Potential Antibacterial Agents.

✍ K. Mogilaiah; R. Babu Rao 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 1 views

Synthesis and theoretical characterizati

Synthesis and theoretical characterization of some new 4-substituted-1,3-diphenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazoles with potential pharmacological activity

✍ Agata Siwek; Monika Wujec; Maria Dobosz; Piotr Paneth 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 90 KB

## Abstract Synthesis of some new triazoles fused to triazoles **5a–c** or thiadiazoles **6a–c** and the thiol‐thione tautomeric equilibrium study of the title compounds are reported. The “rule of five” and complementary criteria of pharmacokinetic properties were determined to predict whether thes