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Isotopically labelled tropane alkaloids. The synthesis of (RS)-[3′, 3′-2H2]- and (RS)-[1′-13C, 3′, 3′-2H2]- hyoscyamines for metabolism studies in plants

✍ Scribed by Stephen Patterson; David O'Hagan

Publisher
John Wiley and Sons
Year
2002
Tongue
French
Weight
101 KB
Volume
45
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A synthetic route to isotopically labelled forms of the tropane alkaloid hyoscyamine, including (RS)‐[3′, 3′,‐^2^H~2~]‐ (2a) and (RS)‐[1′‐^13^C, 3′, 3′,‐^2^H~2~]‐ (2b) hyoscyamines, involving the reaction between phenylacetyl tropine and formaldehyde is described. The isotopically labelled products enable the metabolism of hyoscyamine to be studied in plants such as Datura stramonium. Copyright © 2002 John Wiley & Sons, Ltd.

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