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Synthesis of isotopically labelled [3-14C]- and [3,3-2H2]-5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690), a new antifungal agent for the potential treatment of onychomycosis

✍ Scribed by Stephen J. Baker; Yong-Kang Zhang; Tsutomu Akama; Conrad Wheeler; Jacob J. Plattner; Richard M. Rosser; Ronald P. Reid; Neil S. Nixon

Publisher
John Wiley and Sons
Year
2007
Tongue
French
Weight
113 KB
Volume
50
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

5‐Fluoro‐1,3‐dihydro‐1‐hydroxy‐2,1‐benzoxaborole (AN2690) is a new antifungal agent for the potential treatment of onychomycosis. During the preclinical development phase, it was necessary to synthesize the radioisotope [3‐^14^C]‐5‐fluoro‐1,3‐dihydro‐1‐hydroxy‐2,1‐benzoxaborole and the deuterium isotope [3,3‐^2^H~2~]‐5‐fluoro‐1,3‐dihydro‐1‐hydroxy‐2,1‐benzoxaborole for in vitro studies. We report the synthesis of these two isotopically labelled derivatives. Copyright © 2007 John Wiley & Sons, Ltd.

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