✦ LIBER ✦

The synthesis of 5′-[14C1] and 3a, 4-[13C2] labelled panadiplon (U-78875; 3-(5′-cyclopropyl-1,2,4-oxadiazol-3-yl)-5-(1-methylethyl)-imidazo-[1,5a]-quinoxalin-4(5H)-one).

✍ Scribed by M. J. Ackland; M. R. Howard; L. G. Dring

Publisher: John Wiley and Sons
Year: 1993
Tongue: French
Weight: 318 KB
Volume: 33
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580330609

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

5′‐[^14^C~1~]Panadiplon was prepared in 3 steps starting from [^14^C~1~]cyclopropane carboxylic acid and 3‐(5′‐cyano‐1,2,4‐oxadiazol‐3‐yl)‐5‐(1‐methylethyl)‐imidazo‐[1,5a]‐quinoxalin‐4(5H)‐one. 3a, 4‐[^13^C~2~]Panadiplon was prepared in two steps from ^13^C~2~‐oxalic acid and N‐1‐(1‐methylethyl)‐o‐phenylenediamine. The position of labelling was confirmed by the appearance of two coupled resonances (J~C‐C~=80.59 Hz) at 121.95 and 154.39 ppm in the assigned ^13^C‐NMR spectrum.

📜 SIMILAR VOLUMES

Synthesis of 5-ethyl-1,3,8-trimethyl-1H-

Synthesis of 5-ethyl-1,3,8-trimethyl-1H-[5-14C] imidazo[1,2-c]pyrazolo[3,4-e]pyrimidine

✍ J. L. Hicks; C. C. Huang 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 French ⚖ 246 KB

(1H-Imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox

(1H-Imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine Derivatives: A Novel Class of Potent MSK-1-Inhibitors

✍ Mark J. Bamford; et al. et al. 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 15 KB 👁 1 views

ChemInform Abstract: Synthesis and 5-Hyd

ChemInform Abstract: Synthesis and 5-Hydroxytryptamine (5-HT) Activity of 2,3,4,4a-Tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-Hexahydro-1H-pyrazino[1,2-a]quinoxalines.

✍ Gregory S. Welmaker; et al. et al. 📂 Article 📅 2000 🏛 John Wiley and Sons ⚖ 34 KB 👁 1 views

Synthesis of 7-(4′-fluoro-3,3′,5-trimeth

Synthesis of 7-(4′-fluoro-3,3′,5-trimethyl[1,1′-biphenyl]-2-YL)-3-hydroxy-5-OXO-5-13C-heptanoic acid and trans-6-[2-(4′-fluoro −3,3′,5-trimethyl[1,1′-biphenyl]-2-YL)ethyl]-3,4,5,6-tetrahydro-6-13C-4-hydroxy-2H-pyran-2-one

✍ Gerald E. Stokker 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 French ⚖ 464 KB

Syntheses of 7-phenyl-5h-thiazolo[5,4-e]

Syntheses of 7-phenyl-5h-thiazolo[5,4-e]pyrrolo[1,2-a][1,4]diazepin-10(9h)one,7-phenyl-5h-thiazolo[5,4-e][1,2,3,4]tetrazolo[5,1-c]-pyrrolo[1,2-a][1,4]diazepine and 7-phenyl-5h-thiazolo[5,4-e]-[1,3,4] triazolo [5,1-c]pyrrolo [1,2-a] [1,4] diazepines

✍ A. Shafiee; M. Shekarchi 📂 Article 📅 2002 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 48 KB 👁 1 views

## Abstract Fused tricyclic 7‐phenyl‐5__H__‐thizolo[5,4‐__e__]pyrrolo[1,2‐__a__][1,4]diazepin‐10(9__H__)one (**10**) was prepared by thermolysis of 2‐phenyl‐4‐(1‐pyrrolylmethyl)thiazole‐5‐carbonyl azide (**9**) in acetic acid. In addition, starting from **10**, 7‐phenyl‐5__H__‐thiazolo [5,4‐__e__][

The synthesis of 7-chloro-1-methyl-5-phe

The synthesis of 7-chloro-1-methyl-5-phenyl-1, 3-dihydro-2H-1,4-benzodiazepin-2-one-5-14C and 7-nitro-1-methyl-5-(2′-fluorophenyl)-1, 3-dihydro-2H-1,4-benzodiazepin-2-one-5-14C

✍ H. H. Kaegi; W. Burger; C. J. Bader 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 French ⚖ 393 KB

## Abstract Two benzodiazepines, Diazepam and Flunitrazepam, labeled with carbon‐14 in position 5 of the diazepine ring have been synthesized. Use of a condensation between iminochlorides and ^14^C‐benzonitriles, followed by exhaustive methylation of the resulting quinazolines and hydrolyses is des