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Synthesis of 3H-D-ala2-leu-enkephalin-chloromethyl ketone of high specific activity

✍ Scribed by G. Tóth; J. Hepp; F. Sirokmán; K. Medzihradszky

Publisher: John Wiley and Sons
Year: 1987
Tongue: French
Weight: 283 KB
Volume: 24
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580240716

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✦ Synopsis

Boc-Tyr-D-Ala-Gly was prepared by catalytic tritiation of protected, iodinated tripeptide. The protected tritiated tripeptide and the Phe-Leu-CH2C1 dipeptide were condensed by the mixed anhydride method. The p r o - 3 " tecting group was removed by HC1-methanol. The /JH/-DALECK had a specific activity of 34,2 Ci/mmole /1,27 TBq/mmole/.

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