## Abstract Iptakalim hydrochloride (__N__โ(1โmethylethyl)โ1,1,2โtrimethylโpropylamine hydrochloride) is a promising antihypertensive drug discovered and developed by Beijing Institute of Pharmacology and Toxicology. Deuteriumโ and tritiumโlabelled compounds were designed and synthesized for pharma
Synthesis of 3H- and 14C-labelled 0-(3-morpholinoethoxy)-diphenylether hydrochloride
โ Scribed by Tohru Horie; Takeshi Fujita
- Publisher
- John Wiley and Sons
- Year
- 1972
- Tongue
- French
- Weight
- 206 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0022-2135
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Drotaverinum hydrochloride was labelled with 14C isotope in position 1 of the isoquinoline ring. A rapid synthesis with high radiochemical yield was elaborated. ~ \* Kl'CN was prepared by BBnfi's method5 4C -Drotaverinwn Hydrochloride
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## Abstract The preparation of [^3^H]Sch 727965 from unlabeled compound and tritiated water was base catalyzed. Diethyl [^13^C~3~]malonate was used to prepare [^13^C~3~]Sch 727965 in five steps in 21.8% overall yield. In a similar manner, [^14^C]Sch 727965 was prepared in five steps from diethyl [2