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Synthesis of 2H- and 3H-labelled iptakalim hydrochloride

✍ Scribed by Cheng Zhang; Rifang Yang; Lanfu Chen; Bohua Zhong; Liuhong Yun; Hai Wang

Publisher
John Wiley and Sons
Year
2004
Tongue
French
Weight
110 KB
Volume
47
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Iptakalim hydrochloride (N‐(1‐methylethyl)‐1,1,2‐trimethyl‐propylamine hydrochloride) is a promising antihypertensive drug discovered and developed by Beijing Institute of Pharmacology and Toxicology. Deuterium‐ and tritium‐labelled compounds were designed and synthesized for pharmacokinetic and pharmacological mechanism studies. A derivatization method has been employed in the synthesis procedure. Copyright © 2004 John Wiley & Sons, Ltd.

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