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Synthesis of [2H]-labelled phase-I-metabolites using 1-[2H]-pyridinium hydrochloride

✍ Scribed by Georg Heinkele; Thomas E. Mürdter

Publisher
John Wiley and Sons
Year
2005
Tongue
French
Weight
81 KB
Volume
48
Category
Article
ISSN
0022-2135

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✦ Synopsis

Simultaneous O-demethylation and hydrogen/deuterium exchange of aryl-methylethers can be obtained using 1-[ 2 H]-pyridinium hydrochloride as reagent at 2208C for 6 h. This reaction was applied to dextromethorphan and various non-steroidal antiinflammatory drugs.

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