Synthesis OF 3-[14C]-(p-chlorophenylthio)-2-aminopropane hydrochloride (C 2998-Go)
✍ Scribed by R. K. Maller; K. Nagarajan; M. D. Nair
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- French
- Weight
- 173 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract β‐^14^C‐__p__‐Chloroamphetamine hydrochloride was prepared by condensation of carbonyl‐^14^C‐__p__‐chlorobenzaldehyde with nitroethane followed by lithium aluminum hydride (LAH) reduation of the resulting chloro‐phenylnitropropene. After purfication the overall yield was about 25%. N‐Me
## Abstract A convenient synthesis of the ^14^C‐labelled chloromethyl ketone analog of leucine is reported. Modification of previously published conditions allowed for the facile synthesis of: 2–^14^C‐3‐amino‐1‐chloro‐5‐methylhexan‐2‐one hydrochloride in four steps from 1‐^14^C‐DL‐leucine in 85.7%
Research Centre, Pharma D i v i s i o n HINDUSTAN CIBA-GEIGY LIFlITEO Goregaon, Bombay 400 063, I n d i a S UMMA RY F o r a d d i t i o n a l pharmacokinetic and metabolism S t u d i e s i n l a b o r a t o r y animals and i n humans, Go 10213 was l a b e l l e d w i t h carbon-I4 l o c a t e d on t
## Abstract 3,3‐(^14^C)‐Dimethyl‐1‐phenyltriazene was prepared from recrystallized benzenediazonium fluoroborate which was coupled with ^14^C‐dimethylamine in excess aqueous sodium carbonate at 0°. The crude product was extracted with ether and purified by distillation. Redistilled ^14^C‐labelled t
## Abstract The title compound 9 was prepared by the route outlined in Scheme I. [^14^C]Thiourea (1) was condensed with ethyl 4‐bromo‐3‐oxo‐2‐methoxyiminoacetate (2), providing ethyl 2‐(2‐amino‐4‐[2‐^14^C]thiazolyl)‐2‐methoxyiminoacetate (3), as the pure Z‐isomer. Saponification gave the amino acid