Synthesis of [Imidazolidinone-2-14C]Go 10213 (satranidazole, cibemid®)

✍ Scribed by B. Anjaneyulu; K. Nagarajan

• Publisher: John Wiley and Sons
• Year: 1987
• Tongue: French
• Weight: 249 KB
• Volume: 24
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580240409

✦ Synopsis

Research Centre, Pharma D i v i s i o n HINDUSTAN CIBA-GEIGY LIFlITEO Goregaon, Bombay 400 063, I n d i a S UMMA RY F o r a d d i t i o n a l pharmacokinetic and metabolism S t u d i e s i n l a b o r a t o r y animals and i n humans, Go 10213 was l a b e l l e d w i t h carbon-I4 l o c a t e d on t h e c a r b o n y l carbon atom o f t h e e t h y l e n e u r e a ring (Ring B) o f t h e molecule 2-14C)Co 10213 h a v i n g a s p e c i f i c a c t i v i t y o f 6-06 pCi/mg

( 1 075 mCi/mmol) uas s y n t h e s i s e d s t a r t i n g w i t h [ u r e a i n two steps.