E ) , Bombay 400 063, I N D I A F o r pharmacokinetic and metabolism s t u d i e s i n animals and humans, Go 1C213 was l a b e l l e d w i t h carbon-14 a t t h e 2-position o f t h e 5-nitroimidazole r i n g system, i n a n o v e r a l l y i e l d o f 22% s t a r t i n g w i t h potassium[14C]t h
Synthesis of 14C-labelled 2-aminothiazole, 2-amino-5-nitrothiazole, 2-chloro-5 nitrothiazole, and 1-(5-nitro-2-thiazolyl)-2-imidazolidinone (active substance of ambilhar®)
✍ Scribed by J. W. Faigle; H. Keberle
- Publisher
- John Wiley and Sons
- Year
- 1969
- Tongue
- French
- Weight
- 432 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0022-2135
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📜 SIMILAR VOLUMES
## Abstract A convenient synthesis of the ^14^C‐labelled chloromethyl ketone analog of leucine is reported. Modification of previously published conditions allowed for the facile synthesis of: 2–^14^C‐3‐amino‐1‐chloro‐5‐methylhexan‐2‐one hydrochloride in four steps from 1‐^14^C‐DL‐leucine in 85.7%
l-Methyl-2-nitro-1K-imidazolea carrying d i f f e r e n t 5-side chain. (iaopropyl, hydroxymethylethyl, ethenyl) have been syn- t h e b e d l a b e l l e d with I 4 C a t C2 of t h e imidazole nucleua.
The reaction of [2-14C]-2 ,4-bis-O-(trimethylsilyl)uracil (2) with ~-~-acetyl-~-0-benzoyl-2-deoxy-2-fluoro-~-D-arabinofuranosyl bromide (3) yielded the 3-O-acety1-5-0-benzoyl nucleos e 4 which was hydrolyzed with methanolic ammonia to afford [ 2-feC]-T-( 2-deoxy-2fluoro-p-D-arabinofuranosy1)uracil (