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Synthesis of 2–14C-3-amino-1-chloro-5-methylhexan-2-one hydrochloride

✍ Scribed by Neil J. Lewis; Jan Hes; Philip Yip; Frederick D. Cazer

Publisher
John Wiley and Sons
Year
1977
Tongue
French
Weight
180 KB
Volume
13
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A convenient synthesis of the ^14^C‐labelled chloromethyl ketone analog of leucine is reported. Modification of previously published conditions allowed for the facile synthesis of: 2–^14^C‐3‐amino‐1‐chloro‐5‐methylhexan‐2‐one hydrochloride in four steps from 1‐^14^C‐DL‐leucine in 85.7% yield. This represented a four‐fold improvement over yields reported previously for compounds of this class.

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