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Synthesis and N-methylation of β-14C-p-chloroamphetamine hydrochloride

✍ Scribed by Elizabeth P. Burrows; Elaine Sanders-Bush; H. Joseph Sekerke; Howard E. Smith

Publisher
John Wiley and Sons
Year
1976
Tongue
French
Weight
309 KB
Volume
12
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

β‐^14^C‐p‐Chloroamphetamine hydrochloride was prepared by condensation of carbonyl‐^14^C‐p‐chlorobenzaldehyde with nitroethane followed by lithium aluminum hydride (LAH) reduation of the resulting chloro‐phenylnitropropene. After purfication the overall yield was about 25%. N‐Methyl‐ and N,N‐dimethyl‐ β‐ ^14^C‐p‐chloroamphetamine were prepared, respectively, by LAH reduction of N‐carbobenzoxy – β‐^14^ C‐ p‐chlorpamphetamine and by reductive (Eschweiler‐Clarke methylation of β‐^14^C‐ p‐ Chlolroamphetamine.

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