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Synthesis of [methyl-14C]-N-methylputrescine

✍ Scribed by H. V. Secor; R. R. Izac; S. B. Hassam; A. F. Frisch

Publisher
John Wiley and Sons
Year
1994
Tongue
French
Weight
272 KB
Volume
34
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

[Methyl‐^14^C]‐N‐methylputrescine was prepared from [^14^C]methylamine hydrochloride in five steps. Reaction of benzaldehyde and [^14^C]methylamine (10 mCi) followed by catalytic hydrogenation yielded [methyl‐^14^C]‐N‐methylbenzylamine. The key step in this process is the alkylation of [methyl‐^14^C]‐N‐methylbenzylamine in aqueous medium with 4‐bromobutyronitrile. The radiochemical purity of the final product after two successive catalytic hydrogenations was in excess of 97%. The radiochemical yields in two successive runs were 26 and 38%, based on starting [^14^C]methylamine, with specific activities of 22 and 23 mCi/mmol, respectively. This sequence provides a convenient and efficient regioselective radiosynthesis of [methyl‐^14^C]‐N‐methylputrescine.

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