## Abstract Activated N‐alkyl‐N‐nitrosocarbamates are useful acyl transfer reagents that are employed in the synthesis of N‐alkyl‐N‐nitrosoureas and related N‐nitroso compounds. The nitrosourea products are of chemical and biological interest because they provide access to the __in situ__ generatio
Chemical synthesis of N-(methyl-14C or -3H)-ethyl-N-methyl-N-nitrosocarbamate
✍ Scribed by Adhid Alarif; Suzanne Kimball; Samuel S. Epstein
- Publisher
- John Wiley and Sons
- Year
- 1974
- Tongue
- French
- Weight
- 135 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
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Methyl bromoacetate was reacted with trimethyla~nine-[~'C] dissolved in methanol, forming the methyl ester of [I4C] labeled betaine hydrobromide. The methyl ester was hydrolyzed in an alkaline medium to (carboxymethy1)trimethylammonium hydroxide inner salt, and then transformed into the hydrochlorid
## Abstract [Methyl‐^14^C]‐N‐methylputrescine was prepared from [^14^C]methylamine hydrochloride in five steps. Reaction of benzaldehyde and [^14^C]methylamine (10 mCi) followed by catalytic hydrogenation yielded [methyl‐^14^C]‐N‐methylbenzylamine. The key step in this process is the alkylation of
## Abstract A synthetic procedure for C‐14‐labeled N‐methyl‐N‐nitrosoaniline is presented. Separate labeling of the methyl and phenyl side chains was achieved by using C‐14‐labeled methyl iodide and aniline, respectively. The overall yield of the four reactions was 62% and the final products were s
## Abstract N,N‐[Methyl‐^14^C]‐Dimethylhydrazine hydrochloride () having a specific activity of 115 mCi/mmol, was synthesized in two steps. Dimethylation of acetophenone hydrazone with ^14^C‐methyl iodide (specific activity = 58 mCi/mmol) in the presence of potassium in liquid ammonia followed by a