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Synthesis of N,N-[methyl-14C]-dimethylhydrazine of high specific activity

✍ Scribed by Frederick D. Cazer; Abdul R. Kausar; Kultar S. Kumar; Muthiah N. Inbasekaran; Donald T. Witiak

Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
200 KB
Volume
19
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

N,N‐[Methyl‐^14^C]‐Dimethylhydrazine hydrochloride () having a specific activity of 115 mCi/mmol, was synthesized in two steps. Dimethylation of acetophenone hydrazone with ^14^C‐methyl iodide (specific activity = 58 mCi/mmol) in the presence of potassium in liquid ammonia followed by acid catalyzed hydrolysis of the hydrazone afforded in a yield of 60.0% (>97% radiochemical purity).

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