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Synthesis of (2S : 3R)-4-Dimethylamino-l, 2-diphenyl-3-methyl-2-propionoxybutane-l-14C, d-Propoxyphene-l-14C

✍ Scribed by J. A. Kepler; G. F. Taylor

Publisher
John Wiley and Sons
Year
1970
Tongue
French
Weight
114 KB
Volume
6
Category
Article
ISSN
0022-2135

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✦ Synopsis

d-Propoxyphene, first synthesized by Pohland and Sullivan (la), is a commonly used analgesic. Metabolism studies (2) on racemic N-methyl-14C propoxyphene (3) established that the major metabolic product is the N-demethylated compound. Analytical and metabolic studies performed on d-propoxyphene in these laboratories required optically active radiolabeled drug in which the label would be metabolically secure. The availability of benzylchloride-7-14C suggested the preparation of d-propoxyphene labeled at C-1 .

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