✦ LIBER ✦

The synthesis of SQ-14225-14C [N-[(S)-2-methyl-3-mercaptopropanoyl-1-14C]-L-proline]

✍ Scribed by M. Hasegawa; S. Ohyabu; T. Ueda; M. Yamaguchi

Publisher: John Wiley and Sons
Year: 1981
Tongue: French
Weight: 252 KB
Volume: 18
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580180505

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✦ Synopsis

Abstract

The preparation of SQ‐14225‐^14^C, anti‐hypertensive drug, is described. The starting material, methacrylic acid‐1‐^14^C, was prepared in a high yield by carbonation of the corresponding Grignard reagent with ^14^CO~2~. The final product was obtained from the acid through a four step synthesis with specific activity of 3.20 mCi/mmol. The overall radiochemical yield was 8.0% based on Ba^14^CO~3~.

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