## Abstract A simple and general method for the synthesis of folate analogs labeled in the glutamate moiety with ^14^C is described. The synthesis makes use of the trimethylsilyl derivative of Lโglutamic acid 8 for the coupling reaction with the activated pteroate analogs. Deprotection under mild c
The synthesis of [14C]-L-lysyl-N-(2-benzoyl-4-chlorophenyl)-N-methyl glycinamide
โ Scribed by J. M. Harrison
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- French
- Weight
- 181 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0022-2135
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โฆ Synopsis
A procedure has been developed for the synthesis of L-lysyl-N-(2-benzoyl-4-chlorophenyl)-N-methyl glycinamide labelled with carbon-14. The label was introduced using [14Clcarbon dioxide to prepare the intermediate [carbo~yl-~~C] benzoic acid.
๐ SIMILAR VOLUMES
## Abstract The preparation of ^14^C labelled 1โ(4โchlorophenyl)โ2โmethy 1โ2โaminopropane hydrochloride is described. The radioactive carbon was introduced into the central position of the aminopropyl group in order to study the pharmacological properties and mode of action of the anorexigenic drug
## Abstract The preparation of SQโ14225โ^14^C, antiโhypertensive drug, is described. The starting material, methacrylic acidโ1โ^14^C, was prepared in a high yield by carbonation of the corresponding Grignard reagent with ^14^CO~2~. The final product was obtained from the acid through a four step sy
A synthesis of 3-cyano-4-methyl-5 ( 14 C)-methyl-2-(5-14C)pyrrolyloxamic acid is described. The compound, having specific activity of 66.7 pCi/mmole, was obtained in 19.68% overall yield from uniformly labelled 14C-l-alanine. 14 14 Key Words: 3-Cyano-4-methyl-5( C)-methyl-2-(5-C)pyrrolyloxamic acid,
Preparations are described of the hydrochloride of partially enriched N-methy1-2-(4-nitr0phen[~~O]oxy)ethanamine, N-methyl-2-(4-ni trophenoxy)ethan[ 15N]ami ne , and N-methyl-2-(4-ni tr~[l-~~C]phenoxy)ethanami ne, designated herein as [180]-2, [15N]-2, and [14C]-Z, respectively. rearrangement these