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Synthesis of 24-oxavitamin D3 and 1α-hydroxy-24-oxavitamin D3

✍ Scribed by Luis A. Sarandeses; María José Vallés; Luis Castedo; Antonio Mouriño

Publisher: Elsevier Science
Year: 1993
Tongue: French
Weight: 653 KB
Volume: 49
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(01)86275-x

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✦ Synopsis

Couphng of the CD fragment, ketone 6 (obtamed by pamal synthesis from vitanun D2). either directly (Homer-Wmlg route) or via the denved enol mflate (dlenyne route) with the appropnate A-ring fragment, phosphme oxide amon 7 or enyne 10, 1s the key step m the syntheses of 24-oxavmunm D3 (ld) and la-hydroxy-24-oxavltamm D3 (le), respectrvely HO"

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