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Synthesis of tritiated 1α,25-dihydroxy-22-oxavitamin D3

✍ Scribed by Hiroyoshi Watanabe; Masashi Akiyama; Takehiko Kawanishi; Noboru Kubodera

Publisher: John Wiley and Sons
Year: 1995
Tongue: French
Weight: 563 KB
Volume: 36
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580360706

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✦ Synopsis

Abstract

Synthesis of two tritiated 1α,25‐dihydroxy‐22‐oxavitamin D~3~ (OCT), [26‐^3^H~3~]OCT (3) and [2β‐^3^H]OCT (4), is described. [26‐^3^H~3~]OCT (3) was prepared by tritiation at the side chain with tritiated methylmagnesium iodide and [2β‐^3^H]OCT (4) was labeled at the A‐ring by tritiation with sodium borotritiide.

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