Keywords: 14,
Synthesis of 1α,25-dihydroxy-19-norprevitamin D3
✍ Scribed by Luis A. Sarandeses; JoséL. Mascaren˜as; Luis Castedo; Antonio Mourin˜o
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- French
- Weight
- 211 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
We describe a convergent synthesis of 1ct,25-dihydr(.xy-19-norprevitamin I)3 (3), an analogue of the hormone lct,25-dihydroxyvitamin D3 (lc) that is locked into the previtamin form.
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## Abstract Synthesis of two tritiated 1α,25‐dihydroxy‐22‐oxavitamin D~3~ (OCT), [26‐^3^H~3~]OCT (3) and [2β‐^3^H]OCT (4), is described. [26‐^3^H~3~]OCT (3) was prepared by tritiation at the side chain with tritiated methylmagnesium iodide and [2β‐^3^H]OCT (4) was labeled at the A‐ring by tritiatio
An efficient synthesis of the title compound is reported based on C-l functionalization of the triazoline Diels-Alder adduct of 25-OH previtamin D3 (2). lu,25-Dihydroxy vitamin D3 (la) is considered as the most important and active natural metabolite of vitamin D 1 3 -Recently we have described a no