Synthesis of tritiated 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71)1
✍ Scribed by Hiroyoshi Watanabe; Akira Kawase; Ken Okano; Tetsuya Mitsui; Yoshihiko Ishitani; Kazumi Morikawa; Noboru Kubodera
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- French
- Weight
- 339 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0022-2135
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1␣,25(OH) 2 D 3 is an important negative regulator of parathyroid hormone (PTH) gene transcription. In parathyroid cells, as in other target tissues, 1␣,25(OH) 2 D 3 is degraded by side chain oxidation by the inducible 24-hydroxylase. We have previously shown that one metabolite of this pathway, 1␣,
Keywords: 14,
A three-dimensional model for residues 142-427 of the ligand binding domain (LBD) of the human nuclear receptor for 1␣,25-dihydroxy-vitamin D 3 [VDR] has been generated based on the X-ray crystallographic atomic coordinates of the LBD of the rat ␣1 thyroid receptor (TR). The VDR LBD model is an elon