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ChemInform Abstract: Synthesis and Biological Evaluation of 1α,24-Dihydroxy-25-nitrovitamin D3.

✍ Scribed by Jun-ichi Oshida; Makoto Okamoto; Seiichi Ishizuka; Shizuo Azuma

Publisher: John Wiley and Sons
Year: 2010
Weight: 35 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199923278

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✦ Synopsis

Synthesis and Biological Evaluation of 1α,24-Dihydroxy-25nitrovitamin D 3 .

-The synthesis of an active vitamin D 3 analogue (X), proceeding via palladium-catalyzed alkylative enyne reaction, is described. The corresponding 24(S)-isomer is found to be tenfold less potent than (X).

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