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ChemInform Abstract: Syntheses and Biological Evaluation of Novel 2α-Substituted 1α,25-Dihydroxyvitamin D3 Analogues.

✍ Scribed by Yoshitomo Suhara; Ken-ichi Nihei; Hirokazu Tanigawa; Toshie Fujishima; Katsuhiro Konno; Kimie Nakagawa; Toshio Okano; Hiroaki Takayama


Publisher
John Wiley and Sons
Year
2010
Weight
36 KB
Volume
31
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Synthesis and Biolo
✍ Jun-ichi Oshida; Makoto Okamoto; Seiichi Ishizuka; Shizuo Azuma 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 35 KB 👁 1 views

Synthesis and Biological Evaluation of 1α,24-Dihydroxy-25nitrovitamin D 3 . -The synthesis of an active vitamin D 3 analogue (X), proceeding via palladium-catalyzed alkylative enyne reaction, is described. The corresponding 24(S)-isomer is found to be tenfold less potent than (X).