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ChemInform Abstract: Noncalcemic, Antiproliferative, Transcriptionally Active, 24-Fluorinated Hybrid Analogues of the Hormone 1α,25-Dihydroxyvitamin D3. Synthesis and Preliminary Biological Evaluation.

✍ Scribed by G. H. POSNER; J. K. LEE; Q. WANG; S. PELEG; M. BURKE; H. BREM; P. DOLAN; T. W. KENSLER

Publisher
John Wiley and Sons
Year
2010
Weight
45 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis

Noncalcemic,

Antiproliferative, Transcriptionally Active, 24-Fluorinated Hybrid Analogues of the Hormone 1α,25-Dihydroxyvitamin D 3 .

Synthesis and Preliminary Biological Evaluation.

-New analogues (XII) of the title hormone are synthesized as mixtures of two diastereomers, which are subsequently separated by reverse phase HPLC. The noncalcemic 1-hydroxymethyl group and the fluorinated side-chain, potentiating antiproliferative and transcriptional activities, are the reason for further in vivo biological evaluation of promising compounds (XII). -(POSNER, G.

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