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Synthesis of 25-hydroxy[23,24-3H]vitamin D3

✍ Scribed by S. Yamada; H.K. Schnoes; H.F. DeLuca

Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
534 KB
Volume
85
Category
Article
ISSN
0003-2697

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✦ Synopsis

A synthesis of 25hydroxy [23,24JH]vitamin D3 leading to a radiochemically pure product with a specific activity of 78 Wmmol is described. The structure of the product was confirmed by comparison with unlabeled material and its biological activity was established by in vitro conversion to la,25dihydroxy[23,24-SH]vitamin D, using the chick kidney la-hydroxylase system.

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