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Synthesis of 2,3-disubstituted [3-13C]naphthalenes and [9a-13C]naphtho[2,3-d]-1,2,3-oxadiazole

✍ Scribed by Achim Blocher; Klaus-Peter Zeller

Publisher
John Wiley and Sons
Year
1992
Tongue
French
Weight
514 KB
Volume
31
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis of 2‐amino‐2‐hydroxy[3‐^13^C]naphthalene starting from 2‐(1,3‐dioxolan‐2‐yl)‐benzyl chloride and sodium [^13^C]cyanide in seven preparative steps is reported. Diazotation of the labelled amino compound followed by deprotonation yields [9a‐^13^C]naphtho[2,3‐d]‐1,2,3‐oxadiazole. The β‐^13^C‐labelled naphthalenes prepared are characterized by their ^13^C‐chemical shifts and ^13^C^13^C spin spin coupling constants.

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