✦ LIBER ✦

Synthesis of [20,21-13C2]-pregnenolone

✍ Scribed by Gerardo M. Caballero; Eduardo G. Gros

Publisher: John Wiley and Sons
Year: 1993
Tongue: French
Weight: 222 KB
Volume: 33
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580331004

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✦ Synopsis

Abstract

The synthesis of [20,21‐^13^C~2~]‐pregnenolone (7) from androst‐5‐en‐3β‐ol‐17‐one (1) is described. Labelled carbons were introduced by two procedures, namely, condensation of 1 with K^13^CN and Grignard reaction of nitrile derivative 5 with [^13^C]‐methylmagnesium iodide. Location of labels was confirmed by ^13^C‐NMR spectroscopy.

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