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Synthesis of [21-13C]-cholesterol

✍ Scribed by Gerardo M. Caballero; Eduardo G. Gros

Publisher
John Wiley and Sons
Year
1994
Tongue
French
Weight
205 KB
Volume
34
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis of [21‐^13^C]‐cholesterol (5) from 3β‐O‐(t‐butyldimethylsilyl)‐17β‐cyano‐androst‐5‐ene (1) is described. Labelled carbon‐atom was introduced by Grignard reaction of nitrile derivative with [^13^C]‐methylmagnesium iodide. Location of label was confirmed by ^13^C‐NMR spectroscopy.

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