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Synthesis of [20,21-13C2]-progesterone

✍ Scribed by Gerardo M. Caballero; Eduardo G. Gros

Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
263 KB
Volume
29
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis of, [20,21‐^13^C~2~]‐progesterone (9) from androst‐4‐ene‐3,17‐dione (1) is described. Labels were introduced by two procedures, namely, condensation of 1 with K^13^CN and Grignard reaction of nitrile derivative 7 with [^13^C]‐methylmagnesium iodide. Location of labels was confirmed by ^13^C‐NMR spectroscopy.

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