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Synthesis of cholesterol-20-14C

✍ Scribed by Ana M. Porto; Eduardo G. Gros

Publisher: John Wiley and Sons
Year: 1970
Tongue: French
Weight: 211 KB
Volume: 6
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2590060410

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✦ Synopsis

Abstract

Cholesterol‐20‐^14^C was synthesized in four steps from pregnenolone‐20‐^14^C. The labelled intermediates were proven to be cholest‐5‐ene‐3β, 20α‐diol acetate‐3, cholesta‐5, 20 (22)‐diene‐3β‐ol acetate, and cholesterol acetate by ^1^H‐n.m.r. spectroscopical analysis. Cholesterol‐20‐^14^C was obtained with a radiochemical purity exceeding 99%.

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