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Synthesis of (21-3H3)-pregnenolone

✍ Scribed by V. V. Kris Prasad; Steven O. Franklin

Publisher
John Wiley and Sons
Year
1985
Tongue
French
Weight
225 KB
Volume
22
Category
Article
ISSN
0022-2135

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✦ Synopsis

pregnenolone using pregnenolone as s t a r t i n g m a t e r i a l i e described. The procedure involved r e m o v a l of t h e C-21-methyl group of t h e s t e r o i d and t h e side-chain w a s reconstructed with 3H -CH3MgI i n two steps: a Grignard reaction followed by oxidation of t h e resulting alcohol. An o v e r a l l yield of 71% w a s achieved.

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